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North America accounted for 32.9% of global L-citrulline revenue in 2023, while Europe represents another fast-growing region, supported by strong consumer interest in functional fitness and supplementation

Rotate sites systematically to avoid lipohypertrophy or scarring [10]

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However, interpretation of these signatures may be confounded by kidney function and medication use, and clinical translation will require rigorous external validation, particularly in prospective cohorts and trials specifically designed for DKD

Heldring, N., Kahn, L