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When Hashimoto's disease causes hypothyroidism, patients commonly experience fatigue, cold intolerance, constipation, dry skin, and unintentional weight gain

Most experts recommend long-term or indefinite use, transitioning to a maintenance dose rather than stopping completely, combined with sustained lifestyle changes

Tan Q, Akindehin SE, Orsso CE, et al

References McWhirter L, Smyth H, Hoeritzauer I, Couturier A, Stone J, Carson AJ

Both groups followed a reduced-calorie diet, increased physical activity, and monthly nutritional counseling

In summary, there are evidence, that treatment with GLP-1RAs may prove useful in the treatment of depressive disorders, however, the number of reliable clinical reports concerning this matter remains very low at this point