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This layered approach provides continuous coverage through multiple mechanisms

This stepwise approach minimizes side effects and helps identify the lowest effective dose of each medication

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31 Over time, a third phase of stabilization, erosion and ulceration of the colonic mucosal epithelium may be accompanied by bleeding and the secretion of large amounts of mucus, with relatively stable symptoms that require long-term treatment and management to prevent recurrence

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Consequently [13,22,23,24,25], there is a wide reversal of the shared effect of all the negative events