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Behavioral strategies including self-monitoring (food logs, weight tracking), stress management, adequate sleep (7-9 hours nightly), and social support significantly influence long-term success

GLP-1 acts on the brain to induce feelings of satiety, thus reducing appetite and leading to weight loss

The long-term data on health outcomes for patients with obesity, in particular, is being watched very closely for potential downstream effects of treating the condition

Of note, the finding of a markedly greater benefit on HF of efpeglenatide amongst trial participants using SGLT2 inhibitors at enrolment in the AMPLITUDE-O CVOT highlights another important point (Lam et al., 2021)

2014, S0196-9781 (13): 00431-2

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