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4 Adverse events in PIONEER 3 1,4 Comparator AE rates are not an adequate basis for comparison of safety between products 1 Because clinical trials are conducted under widely varying conditions, AE rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice 1 AE=adverse event

GLP-1 RAs, such as tirzepatide and semaglutide, decrease rates of major adverse cardiac events and mortality in patients with diabetes mellitus, but little data exists on their impact in patients with moderate PAD

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These products are approved for specific medical indications and must follow FDA-authorized labeling, dosing instructions, and quality standards

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