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Finally, the diabetic kidney may be predisposed to chronic tissue hypoxia, in part due to impaired renal perfusion secondary to hyperglycemia-associated microvascular damage

NICE Technology Appraisal TA875 (2023) recommends semaglutide 2.4 mg (Wegovy) for use in adults with obesity or overweight with at least one weight-related comorbidity, when used alongside a reduced-calorie diet and increased physical activity

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