This effect is probably caused by reduction in the effects of corticosteroids, which prevent muscle growth, and even probably by a reduction in the activity of myostatin
Common reasons for deprescribing include No active indication (e.g., health condition resolved) New or worsening condition Potential risks outweigh anticipated benefits Preventive indication with life-limiting conditions Lack of benefit or ineffectiveness Result of a prescribing cascade Nonadherence Interactions or ADEs Prescribers and pharmacists can use the available prescribing and deprescribing clinical tools, but they must also review all medications and assess the benefit versus risk for individualized patients
Some prescribers step the dose down rather than stopping outright, smoothing the return of appetite further, and evidence across the drug class suggests some weight regain is common after stopping, so agreeing in advance what would prompt a return to treatment removes the sting from that possibility
GLP-1 medications have exploded in popularity to manage type 2 diabetes and treat obesity
doi: 10.1001/jama.2018.11406
Although this region contained no known genes, examination of the region with the Vista Genome Browser (Frazer et al
