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Genes involved in tissue repair, collagen synthesis, and antioxidant protection see increased activity, while genes associated with inflammation, tissue breakdown, and cellular aging see reduced expression

doi: 10.1590/S0074-02762004000900011 99 FonsecaCTCunha-NetoEGoldbergACKalilJde JesusARCarvalhoEMet al

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SIRT1 deacetylates NF-B, suppressing its transcriptional activity, which ultimately reduces macrophage infiltration and the release of pro-inflammatory cytokines [38]

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