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Current Pharmaceutical Design , 2011
EMBO J (1999) 18(5):130920.10.1093/emboj/18.5.1309 134 KershawNJMurphyJMLiauNPVargheseLNLaktyushinAWhitlockELet alSOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition
This brief action is heavily dependent on the plasma pseudocholinesterase pathway, as butyrylcholinesterase in the blood hydrolyzes roughly 90% of the drug before it ever reaches the neuromuscular junction
By the time an orally consumed peptide reaches the small intestine, most of it has been destroyed
Beyond synthesis, the compounds were investigated using residue-specific chemoproteomics, enabling deeper insight into their antibacterial properties and helping to explore structureactivity relationships within this class of natural product derivatives
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