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Fmoc-Arg (Pbf) -OH 9.7 g (15mmol), HOBt 2.4 g (18mmol) were weighed, dissolved in DMF, 3.1ml DIC (18mmol) was added in an ice water bath at 0 to activate for 5 minutes, the reaction column was charged, reacted for 2 hours, and then the Fmoc protecting group was removed with DBLK

IP3 may trigger the release of calcium ions (Ca2+) from intracellular stores, while DAG activates protein kinase C (PKC)

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15 found that fentanyl-induced analgesia, decreased tidal volume (Vt) and increased Alveolar-arterial (A-a) gradient (ventilation-perfusion mismatch) 16 , was reduced by a peripherally-restricted -OR antagonist, naloxone methiodide