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The SURMOUNT-1 trial showed up to 20.9% body weight reduction with 15 mg tirzepatide over 72 weeks, compared to roughly 15% with semaglutide in the STEP trials

Irritable pouch syndrome Reduced fertility Anorectal dysfunction (anismus)

[1] [12] For most people, doses up to 2 mg (2000 micrograms) daily are unlikely to cause harm according to NHS guidance, as B12 is water-soluble and excess is typically excreted in urine

However, little is known about the precise effects of the two peptides when administered concurrently

Use modifier 59 only if the injection is separate from other services on the same day

Protocols describe swirling gently, not shaking