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Pickart and colleagues documented that GHK-Cu influences the expression of over 4,000 human genes, with significant upregulation of genes involved in collagen synthesis, DNA repair, and antioxidant defense [1]

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Importantly, PRKAA1 knockdown increased while ectopic AMPK1 expression reduced the sensitivity of Huh7 cells to combination treatment (Extended Data Fig

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Interestingly, GAMT activity was not detected in the head kidneys or proximal intestine in all groups of Phase-II HSB