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In a parallel approach, we reduced glutathione synthetic capacity to approximately 16% of wild-type levels by the exogenous application of 1 mM L-buthionine-sulfoximine (BSO)

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Chronic hyperglycaemia, the production of reactive oxygen species (ROS), and the release of inflammatory cytokines are some of the factors causing endothelial dysfunction in patients with diabetes [11, 12]