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Novo Nordisk, the manufacturer of Wegovy, provides a detailed schedule for Wegovy titration to avoid and reduce possible side effects: The label recommends taking each dose for at least four weeks before escalating to a higher dose to allow your body time to adjust to the medication

Hydrochlorothiazide may increase the risk of kidney (renal) damage when taken with an NSAID

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Lower Calorie Intake May Affect Skin Quality GLP-1 medications often reduce appetite so significantly that overall nutrition patterns change

Because oral absorption may vary, supplements often include precursors such as N-acetylcysteine (NAC) or L-cysteine, which may support endogenous glutathione production