Clinical studies have consistently demonstrated its efficacy in reducing glycated hemoglobin (HbA1c) levels and its favorable safety profile, including a low risk of hypoglycemia and a neutral effect on body weight
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60 ERS also contributes to DPN and DR, with increased IRE1 in the neurons, 61 and upregulated CHOP, caspase 12, and phosphorylated JNK in diabetic retina