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Among them, NOD-like receptor (NLRP3) plays a role in inflammatory body formation and activation, as well as in the regulation of transforming growth factor beta-1 (TGF1), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor ligand superfamily member 2 (TNFSF2), all of which contribute to vascular complications in diabetes [65]

Summary: GLP-1 medications can make you feel cold due to metabolic changes including reduced caloric intake, lower metabolic rate, and loss of insulating subcutaneous fat during weight loss

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