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Researchers utilized the KPC genetically engineered mouse PDAC model (a pancreatic cancer model expressing mutant KRAS and p53 under the Pdx1-Cre drive) to investigate the combined therapy of HDAC5 inhibitor LMK235 (administered intraperitoneally) and anti-PD-1 antibody (200 g per dose, administered intraperitoneally)

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Subsequent research revealed that GHK could influence various cell types beyond liver cells

Further, the peptide has also been found to exert antioxidant effects, while inhibiting carcinogenic receptor expression, giving it anti-tumor effects in breast and colorectal cancer [5, 6]

2016a;39:157986

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