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Nature 496 , 513517 (2013)

- when there is risk of torsades de pointes, for example in patients with prolonged QT, concomitant administration of other medications that produce torsades de pointes (amiodarone, quinidine, bepridil, IV erythromycin, halofrantine, pentamidine, sparfloxacin, sultopride, vincamine, betrilio, disopyramide, sotalol, etc)

Researchers often study it in lab work on Nicotinamide N-Methyltransferase (NNMT)

Unlike some supplements, it is also regulated

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