Earlier, the available antiviral therapies were effective in the treatment of HCV infection only at early stages and its identification and treatment at chronic stage were generally meaningless
In addition, TMAO was suggested to activate NFB, likely through a G-protein coupled receptor G signaling pathway in endothelial cells and vascular smooth muscle cells, leading to enhanced expression of proinflammatory cytokines and leukocyte adhesion to endothelial cells in vitro (Seldin et al., 2016)
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10.1016/j.phymed.2020.153370 100 LuL.-Q.TianJ.LuoX.-J.PengJ
