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When CYP1A2 (Phase I) oxidizes an aromatic amine to its N-hydroxy derivative, and then O-acetyltransferase activity (catalyzed by the same NAT enzymes) transfers an acetyl group to the oxygen, it creates a highly reactive N-acetoxyarylamine that binds DNA

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What we are recommending is that if you experience a change in your vision while using one of these drugs, you should consult the prescribing doctor and see an ophthalmologist

This point is marked accordingly to the point of the medial nasal sill on the non-cleft side, MNSR