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This acquired, degenerative condition is characterized by drusen deposits that interfere with the retinal pigment epithelium (RPE) and Bruchs membrane, specifically affecting the macula, which is essential for central, detailed, and color vision [410]

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Continued use of these models, including newer ones like gut organoids with human microbiota or brain-gut chip systems, will allow dissection of how specific microbes or metabolites act on specific brain cell types