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Semaglutide produced less weight loss than tirzepatide head-to-head, about 14% versus 20%. Its body-composition substudy measured a roughly 62:38 fat-to-lean loss split by mass, compared with about 75:25 for tirzepatide in a separate trial. The scan overstates muscle loss because lean mass includes water and organ tissue

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The full 20-week titration uses approximately 23.5mg of semaglutide total

The other authors declare they have no financial interests

Take home message Mounjaro can cause pancreatitis, but this side effect is rare, occurring at rates similar to those of the placebo in clinical trials (0.32-0.39%)