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Giovenali P, Fenocchio D, Montanari G, et al

With age, oxidative DNA damage increases, leading to excessive PARP-1 activation which depletes NAD+ reserves

Ajoene also upregulates NAD(P)H:quinone oxidoreductase-1 (NQO1) by activating ERK and Nrf2 in non-tumorigenic MCF-10A cells, enhancing antioxidant responses (Cho et al

We also identified differential responses based on exposure age and with respect to BPA concentration