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This activity of polyphenols results from a combination of iron chelating and radical scavenging properties, but also refers to the inhibition of lipoxygenase (LO) [72], cyclooxygenase (COX) [73], myeloperoxidase (MPO) [74], NADPH oxidase [75], and xanthine oxidase (XO) [76], preventing the generation of ROS [77] as well as organic hydroperoxides [78]
Indeed, the components of this system are involved in the bi-directional transport of acyl moieties from cytosol to mitochondria and vice versa, thus playing a fundamental role in tuning the switch between the glucose and fatty acid metabolism
In a study involving adolescents aged 12 to 18 years with a body mass index of 30 kg/m2 or higher, those who used liraglutide (3.0 mg) for 56 weeks showed a significant weight loss of 3.2%, as compared to a weight gain of 2.2% in the control group
Expert testimony preparations
- **Naltrexone/Bupropion (Contrave)**: Influences hypothalamic appetite centers and the reward system to reduce cravings, with side effects like nausea, headache, and contraindication in seizure disorders