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Unlike traditional phosphodiesterase-5 inhibitors that target vascular function, PT-141 acts centrally through brain melanocortin pathways, making it the first centrally-acting agent approved for sexual dysfunction

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The Wnt/-Catenin pathway is a complex signal transduction process wherein phosphorylated GSK3 captures -Catenin and triggers its degradation

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63 Nianiou-ObeidatI.MadesisP.KissoudisC.VoulgariG.ChronopoulouE.TsaftarisA.et al (2017)