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Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy: phase 2 randomized trial results

ObunikeJCLutzEPLiZPakaLKatopodisTStricklandDKet alTranscytosis of lipoprotein lipase across cultured endothelial cells requires both heparan sulfate proteoglycans and the very low density lipoprotein receptor

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Mario Vitale, University of Salerno, Italy Updates Copyright 2021 Lanzolla, Marin and Marcocci

Together, these results suggest G6P sensing, but not Tps1 catalytic activity, is sufficient to restore resistance to oxidative stresses in tps1 strains

These findings collectively emphasize that gut dysbiosis, increased intestinal permeability, and even gutlung microbial translocation can amplify neuroinflammation and worsen ischemic stroke outcomes, underscoring the need to consider the gutbrainlung axis as a potential target for improving stroke prognosis