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Resmetirom (Rezdiffra TM ), a liver-directed thyroid hormone receptor- (THR-) agonist, received accelerated FDA approval in March 2024 as the first agent specifically indicated for non-cirrhotic MASH with moderate-to-advanced fibrosis (F2-F3), based on the MAESTRO-NASH trial demonstrating MASH resolution and fibrosis improvement

25, 38 Identical results were also obtained for all cell lines tested with BSO+L-PAM when cultured in standard culture conditions (room air+5% CO 2

McFarland LV, Surawicz CM, Greenberg RN, et al

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Advances in patented CB1 receptor antagonists for obesity