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Patients should also be aware that folate supplementation should not be started before B12 deficiency has been treated, as doing so can precipitate or worsen neurological complications

Vitamin B12 is needed for conversion of homocysteine and therefore can help prevent conditions or complications like heart attack, stroke or coronary heart disease

NAD+ itself is the coenzyme that mitochondria burn through to make ATP and that sirtuins and DNA-repair enzymes consume as fuel

Aging can also set you up for a B12 shortage since absorption declines as you get older

Different mechanisms, different side-effect profiles

The dose is adjusted as needed to get the best results