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In the -cell, PC1/3 is up-regulated, resulting in increased processing of proglucagon to GLP-1 while DPP-4 is down-regulated in order to reduce degradation and enhance local intact GLP-1 concentrations

doi: 10.1016/j.molmet.2021.101351 13 WenJSyedBNadoraDHow-VolkmanCBernsteinETruongAet al

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Nature (1993) 362(6415):759

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