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**Diarrhea or Constipation**: Patients may experience changes in bowel habits

The full titration schedule typically spans 16 weeks, with dose increases every four weeks: 0.25 mg (weeks 14), 0.5 mg (weeks 58), 1.0 mg (weeks 912), 1.7 mg (weeks 1316), and 2.4 mg (week 17 onward)

doi: 10.3389/fimmu.2019.02318 163 SelleABrosseauCDijkWDuvalABouchaudGRousseauxAet al

Continue working with your healthcare provider on appropriate analgesic strategies

If adherence and lifestyle factors are optimised but glycaemic control remains inadequate, your doctor will consider treatment intensification in line with NICE guidelines