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It is worth noting that Fig.3 highlights four major issues affecting the effectiveness and safety of Se-based treatments: (1) a narrow therapeutic window requiring precise dosing to avoid toxicity or ineffectiveness

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[36] found that terpenoid like compounds such as Lup activate the Keap1-Nrf2-ARE pathway

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inhibition of root growth, inhibition of root cell division, modification of the cytoskeleton and inhibition of nutrient uptake (Kaur et al., 2019)

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To address these oversimplifications, the mechanisms involved are scrutinized below (Fig

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