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Key message: Pyrazinamide induced hyperuricemia, a component of anti-TB therapy, reduces renal uric acid excretion often leading to hyperuricemia and in some cases acute gout flares

Li Z, Duan Y, Zhang F, Luan H, Shen WT, Yu Y, et al

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The optimal timing depends heavily on your specific research objectivesare you investigating gut health, musculoskeletal recovery, or systemic inflammation

After a period (often about a month or as advised by your doctor), the dose may be increased to a higher strength (e.g., 7 mg or more) based on clinical response and tolerability

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