In the present study, we have not only unveiled the interaction of endosomal GLP-1R with the ER, but also its localisation to VAPB-containing ERMCSs, from where the receptor assembles a newly described PKA signalling nanodomain, enabling cAMP-dependent PKA activation at the interface between the ER and mitochondria
I., Perumal, S
Mechanisms of action and therapeutic application of GLP-1 receptor agonists
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If cost, side effects, or maintenance dosing is the concern, dosing should be individualized with the prescribing clinician
Nadar R, Phadke N, Khatod K, Khadilkar V, Khadilkar AV (2014) Clinical applicability of rapid detection of SRY and DYS14 genes in patients with disorders of sex development using an indigenously developed 5 exonuclease based assay