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Side-by-side comparison Factor Receptor targets Semaglutide GLP-1 only Tirzepatide GLP-1 + GIP Retatrutide GLP-1 + GIP + glucagon Liraglutide GLP-1 only Factor Half-life Semaglutide ~7 days Tirzepatide ~5 days Retatrutide ~6 days Liraglutide ~13 hours Factor Dosing frequency Semaglutide Once weekly Tirzepatide Once weekly Retatrutide Once weekly Liraglutide Once daily Factor Max studied dose Semaglutide 2.4 mg/week (SubQ)
extending time between injectionsand what are the pros and cons of each
GLP-1
Time + Age Factors The longer the skin has been stretched, due to weight gain, pregnancy, menopause, or simply time, the less likely it is to contract after fat loss
Obesity, 29 (7), 1102-1113
Struggling with fatigue and a slow metabolism
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