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The effect of semaglutide and GLP-1 RAs on risk of nonarteritic anterior ischemic optic neuropathy

Chemically, retatrutide is a longacting, multireceptor incretin mimetic engineered to coactivate the glucagonlike peptide1 (GLP1R), glucosedependent insulinotropic polypeptide (GIPR), and glucagon (GCGR) receptors

According to Table 1, comprehensive experimental and observational studies reveal that GLP-1RAs do not elevate overall cancer risk, while preclinical investigations have demonstrated multiple anti-tumor mechanisms, including proliferation inhibition, apoptosis induction, and metastasis suppression

You start at 0.25 mg weekly for the first four weeks, then increase to 0.5 mg for weeks 5 through 8, then 1 mg for weeks 9 through 12, then 1.7 mg for weeks 13 through 16, and finally the maintenance dose of 2.4 mg from week 17 onward

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Appropriate Dosing Times: Morning time in shower