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Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11

Combined, these effects can offset or amplify depending on your baseline metabolic state

& Strain, J

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Peptide-based cancer vaccines have shown promising immune responses but have not yet consistently demonstrated strong clinical outcomes across all patients