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Importantly, the current evidence supporting this approach is largely indirect and derived from studies conducted in patients with established PsO and metabolic comorbidities, rather than in well-characterized early PsA cohorts.An additional and largely underexplored aspect concerns the safety of combining GLP-1RAs with bDMARDs

The pathogenesis of DKD involves a complex interplay of metabolic, hemodynamic, inflammatory, oxidative, and fibrotic pathways

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GLP-1 medications can cause side effects ranging from mild nausea to severe complications like pancreatitis or kidney problems

The chart below shows the expected mortality impact of these scenarios at the population level