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Oral melanotic lesions usually account for 1520% of all the intra-oral lesions and more often than not, such pigmented lesions are first confronted by the primary care physicians.[16] Once the endocrine, post-inflammatory, and tobacco-related causes are excluded, it is imperative for primary care physicians to consider the inherent malignant potential of such pigmented lesions (melanotic macule/melano-acanthoma) to develop into melanoma and exercise caution with immediate effect for early detection and interception

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Cardiac arrhythmias reported across the trials were generally mild to moderate

doi: 10.1172/JCI186420

de Kloet, Chapter 3.4 - Corticosteroids and the blood-brain barrier, Editor (s): T