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While short-term anti-inflammatory effects can be helpful, long-term immune regulation --- especially in patients with autoimmune conditions --- needs careful monitoring

Resistin is mainly secreted from adipose tissue in mice whereas it is mainly secreted from monocytes in humans

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The schedule follows the standard pathway through 2mg and 4mg, then maintains at 8mg: Weeks 1-4: 2mg weekly Weeks 5-8: 4mg weekly Week 9+: 8mg weekly (maintenance) This reaches maintenance 4 weeks sooner than the 12mg protocol and avoids the final dose escalation that many researchers find most challenging