23 April 2025 A Correction to this paper has been published: Abbreviations BBB: Bloodbrain barrier CNS: Central Nervous System GFAP: Glial fibrillary acidic protein GLP-1R: Glucagon-like peptide-1 receptor HFD: Highfat diet IB4: Biotinylated isolectin B4 Iba-1: Ionized calciumbinding adaptor molecule-1 ND: Normolipid diet NVU: Neurovascular unit SAL: Saline solution SEMA: Semaglutide References Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C
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Although preclinical studies suggest that GLP-1RAs may attenuate Alzheimers disease (AD) progression [44, 45], phase III semaglutide trials (NCT04777396, NCT04777409) did not demonstrate clinical benefit
Patients should maintain records of pharmacy dispensing dates and opening dates
Patients using Wegovy should follow a balanced, nutrient-dense diet in line with NHS healthy eating guidelines, and healthcare professionals may consider checking micronutrient levels if deficiency symptoms develop
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