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Additionally, ergosterol (ER) has been found to enhance Nrf2 activity, inhibiting molecules related to ferroptosis, such as MMP-9 and MMP-13, which strengthens the cells resistance to oxidative stress and protects chondrocytes from damage (Cai et al., 2021)

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Safe Use, Mitigation Strategies, and When to Consult Your Provider To minimize glutathione depletion risk: stay within recommended dosing limits (maximum 3,0004,000 mg/day for adults), avoid chronic daily use without medical guidance, maintain adequate nutrition (protein, vitamins B6 and C support glutathione synthesis), and consider alternatives like physical therapy or NSAIDs where appropriate