Side Effects Profile All three medications share common side effects, primarily gastrointestinal: Nausea (usually temporary, worst in first few weeks) Diarrhea or constipation Abdominal discomfort Reduced appetite (this is the goal, but can feel uncomfortable initially) The higher dose of Wegovy may cause more pronounced side effects initially, while Saxendas daily dosing can offer more stable blood levels with potentially fewer ups and downs
But it also reflected the importance of the milestone in cloning the receptor
There are two approaches (and its possible to combine both): Stay at the Starter Dose
Several metabolic adaptations make it challenging to sustain weight loss long-term, including hormonal changes, increased food noise, and the energy gap. Shifts in Hunger Hormones Hunger and satiety are partially driven by hormones released from the gut to the hypothalamus (a region of the forebrain)
ISSN 2165-1736
Given the known side effects of GLP-1s such as intestinal discomfort and muscle loss, most people have trouble staying on them for more than a year and the weight loss is often reversed once they stop
