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Future directions should focus on integrating multiomics platforms (e.g., single-cell transcriptomics and spatial proteomics) to refine target selection paradigms while leveraging engineering innovations to lower translational barriers, ultimately bridging the gap between preclinical validation and clinical implementation

Mol Cell Biochem 348(1-2):8998

For example, in a study from the Journal of the American Medical Association , patients achieved around 5.9% loss of their total body weight in three months

Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration

But it will take years before researchers get a full picture of these effects