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Depression patients exhibit reduced parasympathetic activity and relative sympathetic hyperactivity, and this autonomic imbalance inhibits the generation and propagation of propulsive intestinal contractions ( Interstitial cells of Cajal (ICC) dysfunction represents the cellular basis of gut dysmotility

Studies have found the chemokines levels, such as CXCL13, CXCL9 and CCL2, are significantly increased in MS (115, 116), potentially activating the p38 mitogen-activated protein kinase (MAPK) pathway and compromising the BBB (117)

From my experience, once patients see how easy it is, even if theyre initially nervous, they often feel confident enough to continue the medication long term

Your body will process it

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