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(19) Cystic fibrosis leads to suppressed glutathione levels and the impaired ability to produce more at a normal rate

The DHS-led survival advantage of mice was accompanied by an increase in the total GPx activity as well as mRNA expression levels of seleno-GPxs ( GPx1 , GPx2 , GPx3 , and GPx4 ), reduction of lipid peroxidation, and suppression of inflammatory response (decrease of the expressions of pro-inflammatory genes and infiltration of inflammatory cells) in the radiosensitive organs such as spleen, intestine, and lung

The beneficial significance of the egr-1 gene implies the healing process (i.e., trans-activation of many cognate target genes in healing tissue, including growth factors and cytokines (Zhang et al., 2011)

However, modern technology has provided a new solution: liposomal delivery

doi: 10.1016/j.molcel.2018.01.024 80 WaldenMTianLRossRLSykoraUMByrneDPHeskethELet al

(2018) 175:178095 e19