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Given that decreases in NAA are often interpreted as reflecting neuronal dysfunction whereas the basis for NAA increases remains less clear 79 , the absence of tNAA changes in our regions of interest may reflect this heterogeneity across models, brain regions, and experimental conditions

The differences are in degree

However, semaglutide has a longer track record and more extensive safety data

The closest published human safety data is for CB4211 , a synthetic MOTS-c analog that completed a Phase 1 trial and was reported as well tolerated

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