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Oct 10 2006;609(1):17-25

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Subsequent cloning of the rat preproglucagon gene showed that it contained glucagon and two additional peptides designated GLP-1 and GLP-2, and that the anglerfish GRP is a GLP-1

[Note: This reaction is analogous to the formation of cyclic AMP by adenylate cyclase, except that this guanylate cyclase is not membrane associated.] The resultant rise in cGMP causes activation of protein kinase G, which phosphorylates Ca 2+ channels, causing decreased entry of Ca 2+ into smooth muscle cells

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Section Summary: L-carnitine is a naturally occurring amino acid derivative that plays a critical role in cellular energy production by transporting fatty acids into the mitochondria