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BI2536 blocked osteosarcoma cells (KHOS and U2OS) in the G2/M phase, thereby effectively inducing mitotic arrest and apoptosis

Because the molecule is delicate and subject to chemical and physical degradation (peptide bond hydrolysis, oxidation, aggregation, microbial contamination), how it is stored and how long it remains effective (its shelf life) become critical for anyone handling it

Careful optimization of IN dosing regimens will be essential for maintaining efficacy, minimizing side effects, and increasing patient compliance

Serious but rare effects include pancreatitis or gallbladder issues

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Perioperative BPC-157 administration in surgical patients represents a potential application requiring safety and efficacy validation in clinical trials with surgical outcome measures