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Moreover, a natural compound of the tetraterpene group from tomatoes, lycopene (10 mg/day, P.O for 2 months), was reported to significantly increase the ratio of serum TAC to MDA in patients with type 2 diabetes [149]

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Ethics declarations Competing interests KGW and VJNB are co-founders and shareholders of Aprea Therapeutics AB, a company that develops novel p53-based cancer therapy

The above study represents just the beginning of their research pipeline

10.1038/s41591-019-0375-9 Nat

Protein degradation by the UPS is executed through a complex three-step enzymatic cascade involving ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2) and ubiquitin ligases (E3)