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DSIP has paradoxical stability characteristics: it is rapidly degraded by blood enzymes with a half-life of minutes, yet its sleep-normalizing effects persist for days to weeks after administration

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Following delivery of a therapeutic dose of paracetamol to a healthy person, the majority of paracetamol is directly conjugated in the liver by phase II enzymes to form glucuronide (APAP-glu) and sulphate (APAP-sul) derivatives

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This review explores the importance of the mercapturic acid pathway and the potential of intra-tumor activation of old and recently discovered chemotherapeutics